BTEC Introduction to Chemical Modification of Protein Therapeutics
Chemical modifications of protein therapeutics are common across approved drugs. Numerous examples exist, including PEGylated protein therapeutics, which have polyethylene glycol (PEG) chains attached to the protein to increase the systemic half-life in the body. In addition, there are a number of antibody-drug conjugates (ADCs) on the market that consist of an anti-cancer agent linked to an antibody for targeted delivery of the agent to a specific tumor.
This online course provides participants an understanding of important modification methods applied to protein therapeutics. It offers a unique opportunity to learn about the processes, analytical methods, and regulatory considerations for the design and execution of GMP processes for chemically modified biopharmaceuticals.